Introducing
National Institute of Biotechnology Malaysia Research Project
Research Project
The core business of NIBM is R&D for the generation of new knowledge and technology innovation. MGI, IPharm & ABI conducted research projects being funded by ministries and also some collaboration with local and international universities or research institutions/organisations.
ROLLING PLAN
No. | PROJECT TITLE | Duration |
1. | Malaysia Genetics and Living Culture Collection: Safeguarding Research, Development, Innovation And Commercialization Of Biological Materials (NEW) | 1 year (2020) |
2. | Program Pembangunan Mampan Benih Rumpai Laut Bagi Industri Aquakultur | 3 years (2018-2020) |
3. | COMMERCIALISING AN INTEGRATED AAALAC ACCREDITED SPF SMALL LABORATORY ANIMALS BREEDING AND NON-CLINICAL STUDIES RESEARCH CENTRE | 4 years ( 2017-2021) |
4. | Establishment of a technology platform for pharmaceuticals, nutraceuticals and cosmeceuticals product development and national natural product repository R&D&C | 2 years 2016-2018 |
DSTIN FLAGSHIP Program/ Pre-Commercialisation Projects (10th MP)
No. | PROJECT TITLE | Duration |
1. | New Technologies for sustainable Bio-Economy : Construction of microbial Cell Biocatalyst for Production of Biobased Fine Chemicals. | 2 years |
2. | Enhancing The therapeutic potential of rAF Newcastle Disease Virus Cancer Vaccine. | 2 years |
3. | Development of a natural products library from Malaysian biodiversity for systematic discovery of potential active therapeutic agents for obesity | 3 years |
4. | Drug-drug and Drug-herb interactions screening platform, a comprehensive high throughput safety testing service for drugs, nutraceuticals and standardized herbal medicine in IPharm | 3 years |
5. | Development, Evaluation And Integration of Innovative Tools To Reduce Dengue Morbidity And Mortality In Community | 3 years |
6. | Enhancing the Productivity of Farm Buffalo (Bubalus Bubalis) Through Modification of Rearing Practices | 3 years |
INTERNATIONAL COLLABORATION
No. | PROJECT TITLE | COLLABORATOR |
1. | Structural Genomics of the Extremophilic Microbes Leucosporidium antarticum and Bacillus lehensis G1 | Monash University (Prof. Jamie Rossjohn) |
2. | New Technologies for Sustainable Bio-Economy: Construction of Microbial Cell BioCatalyst for Production of Biobased Fine Chemicals | Concordia University, Montreal, Canada (Prof. Adrian Tsang) |
FUNDAMENTAL RESEARCH GRANT SCHEME (FRGS)-MOE
No. | PROJECT TITLE | Year |
1. | Identifying the Novel Features of Diacylglyceryl Transferase (LGT) Membrane Enzyme in Leptospirosis – causing bacteria | 2019-2021 |
2. | Elucidation Of Crystal Structure And Function Of Enzymes With Phenol Removing Activity From Geobacillus. | 2019-2022 |
3. | Elucidation of the Mechanism of Action And Signal Transduction Pathway Activated by Two Natural Compounds with Anti- Diabetic Potential | 2017-2020 |
4. | Isolation and structure elucidation of bioactive compound(s) from khaya senegalensis (DESR.) A. Juss. Leaves with wound healing activity” | 2019-2021 |
5. | Mechanistic studies on the mode of actions of standardised bilimbi fraction and its natural compounds in brown fat differentiation program | 2019-2021 |
6. | Iron Biofortification Of Malaysia Rice Using Targeted Genome Editing Approach | 2014-2016 |
7. | Development Of New Strains Of Tiger Milk Mushroom (Lignosus Sp) | 2014-2016 |
8. | Determination the Effects of Indigenous Silage Bacteria and Its Associated Bacterial Communities using Conventional and Next Generation Sequencing Approaches Towards Improved Silage Quality | 2018-2020 |
SMARTFUND (MESTECC)
No. | PROJECT TITLE | Year |
1. | RapidRAW Screening Technology: Fake Honey Detection | 2019-2021 |
MOSTI SPECIAL ALLOCATION
No. | PROJECT TITLE | Year |
1. | Large scale production of tuber of Tiger’s Milk Mushroom (Lignosus rhinocerus) | 2015-2017 |
2. | Identification Of The Growth And Development Of Termitomyces Heimii | 2015-2017 |
3. | Proteomics Of Termitomyces heimii At Different Developmental Stage | 2015-2017 |
4. | Smart System For Shiitake Mushroom (Lentinula edodes) Cultivation | 2015-2017 |
5. | Development of Nutraceutical and Pharmaceutical Products for Therapeutic Indications or Disease of High Burden to Malaysia | 2015-2018 |
GRANT AWARD
No. | PROJECT TITLE | Year |
1. | Skim Sequencing Of 96 Heterotrigona Itama Genome (Grant Award by Illumina 2017) | 2017-2018 |
LOCAL RESEARCH COLLABORATION
No. | PROJECT TITLE | LEAD BY |
1. | Genome Sequencing of local isolates bacteria Lysinibacillus sp. and Enterobacter sp. | UKM |
2. | Analisis Mikrobiom yang Terlibat dalam Patogenesis Ganoderma Boninense Terhadap Pereputan Pangkal Batang Pokok Kelapa Sawit, Elaeis guineensis | UKM |
3. | Molecular Characterization of Familial Hypercholesterolemia (FH) in a Malay Population via Exome Sequencing | UMBI |
4. | Proteomics Footprinting of Tecotrienols-treated Human Breast Cancer Cells. | UM |
5. | Genomic Diversity of Malaysian Aborigine (Orang Asli). | UMBI |
6. | Genome and transcriptome analyses of four Burkholderia pseudomallei isolated from Malaysia | UKM |
7. | Genome Sequencing and Analysis of Rhodococcus sp. | UNISEL |
8. | Comparative Genome Analyses and Phylogenomics Studies of Land and Marine Iguanas from the Galapagos Island | UKM |
9. | Functional characterization of hypothetical protein from Burkholderia pseudomallei | UKM |
10. | Structural Elucidation of Human APOBEC3B, a Cytosine Deaminase implicated in Cancer | UTM |
11. | Elucidation of the Neuro – Regenerative Signaling Pathway in Diopatra Claparedii | UMT |
12. | Unraveling the enzymes involved in dimerization of resveratrol. | UiTM |
13. | Pemuliharaan Genetik Kelip-kelip Pteroptyx tener (Coleoptera: Lampyridae) di Kuala Selangor | FRIM |
14. | Generation and Characterization of The Rafflesia Genome Sequence | UKM |
15. | Soil microbiome analysis of oil palm for potential Basal Stem Rot disease control | UPM |
16. | Comparative Genomics Of Rafflesia | UKM |
17. | Highland Stingless Bee Identification And The Assessment Of Domesticated Stingless Bee At High Altitude | UKM |
18. | Functional Studies of Mating Pheromones in Oil Palm Pathogen, Ganoderma boninense to Elucidate Its Pathogenicity | UKM |
19. | Targeted genomic Profile of Malay B-Thalassemia Patients by Using NGS | USM |
20. | Penghasilan Madu Premium Berasaskan Inovasi Mustafa-Hive dan Hilda-Sistem | USM |
21. | Determination of Molecular Characteristics and Cytotoxicity of Polyphenol from Aquilaria sp. (Gaharu) as Lipase Inhibitor in Obesity Treatment | UPSI |
22. | Visualization model of biocatalysis remediation by polycyclic aromatic hydrocarbons-degrading enzymes through functional and structural characterization | UPSI |
23. | Elucidation of structure and function of conserved hypothetical proteins related to thermal stress response in psychrophilic bacterium and yeast | UMS |
24. | Mangosteen research sustainability using multi-omics integration and database development | UKM |
25. | Projek FRGS-MRSA: Characterisation of nonporous biochar-derived adsorbents from tropical biomass | UPM |
26. | Insights into the evolution of fiddler crab through whole genome comparison between Uca rosea with Uca annulipes | USM |
27. | Role of recombinant protease derived from Malaysian belacan on eschar and biofilm removal for necrotic wound healing | UTM |
28. | PCOS analysis | LPPKN |
29. | Cell Permeability and Bioavailability Evaluation of Citropten and its Anti-Inflammatory Properties in a Rat Model Inflammation | IMR |
30. | Oral pharmacokinetic evaluation of freeze-dried Carica papaya leaves juice formulations in rats | IMR |
31. | The Possible Use of Mitochondria as Indicator in Production Yield and Abnormality of Oil Palm | MPOB |
32. | Traceability and Authenticity of Honey and Kelulut Honey | BKKM (MOH) |
33. | Development of entomopathogenic fungi as biocontrol agents against dengue vectors | Swinburne University of Technology Sarawak Campus |
34. | Fitness assessment of dengue diagnostic methods for safe utilisation | UM |
35. | Safety of blood and tissues supply | UM |
36. | Dengue in marginalized populations | UM |
37. | Point of care test (POCT) for Dengue | UM |
38. | An integrated microfluidics system for rapid serotype-specific detection of dengue virus infection | UM |
39. | Development of New Tools for the Diagnosis and Management of Dengue in Local Communities (CLINICAL) | Monash University |
40. | Multi-Centre Field Trial diagnostic Kit for the Identification of potential severe dengue (PARA CLINICAL) | UM |
41. | Production and trial use of Spokojan (Community Empowerment) | UM |
42. | Design and synthesize lead compounds for anti-dengue based on the bioactive natural products and novel L-thionucleoside pyrimidine analogues using Vorbruggen Coupling Method | UKM/USM |
43. | Elucidation of Immune modulatory molecules from Carica papaya extract against Dengue fever | USM |
44. | Investigation of the effects of natural products in reducing the progression of atherosclerosis | UMT |
45. | Progressing towards discovery of anti-infective entities from natural product: Elucidation of pathways involved in anti-infective using the Caenorhabditis elegans model system | USM |
46. | Development of a natural products library from Malaysian biodiversity for systematic discovery of potential active therapeutic agents for obesity | UKM, USM, UM |
47. | Molecular Biopharming of Nipah Virus Surface Antigens for The Production of Recombinant Vaccine | MARDI |
48. | Development of Vaccines Against H5N1 and Characterization of The Vaccine Induced Immune Responses and Immunity | UPM |
49. | Advanced Reproductive Biotechnology of Seladang and Banteng | MARDI |
50. | Application of Advanced Reproductive Biotechnologies for Breeding and Mass Propagation of Malayan Porcupine (H. brachyurus) | PERHILITAN |
51. | Genetic Characterization and Intensive Breeding of Malaysian Barking Deer (Kijang) in Developing It As An Alternative Food Source, A Model for Ruminant Health Research and Agro-tourism | UPM |
52. | Development and Evaluation of Fermented PKE Based Feed for Poultry and Fish | MARDI |
53. | Bio-processed OPF as animal feed | MARDI |
54. | Bio-processed Palm Oil Mill Effluent (POME) for Poultry Feed | MARDI |
55. | Development of A Recombinant Single Cell Protein Organism Capable of Bio-synthesizing High Unsaturated Fatty Acids as Feed for Aquaculture | USM |
56. | Phylogenetics and Molecular Characterization of The Variant Surface Glycoproteins (VSGs), and Antigenic Repertoire of Trypanosoma evansi in Malaysia | UPM |
57. | Process Improvement Of Newcastle Disease Virus (NDV) Vaccine Production In Bioreactor | IIUM |
58. | Development of Diagnostic Kit for Detection of Nodavirus from Aquaculture Marine Fish | UMS |
59. | Molecular Epidemiology and Pathogenesis of Streptococcus Infection in Caged-cultured Freshwater Fishes | FRI |
60. | Production Red Fermented Rice as An Alternative for Feed Ingredients for Development Low Cholesterol Eggs and Low Cholesterol Prawns | MARDI |
61. | Reproductive, Breeding and Culture Technologies for Commercial Production of Kelah, Tor spp. | UPM |
62. | Development of Antioxidant-rich Products from Local Fruits | MARDI |
63. | Molecular Markers for Quality Control of Clonal Oil Palm | MPOB |
64. | Tissue-specific Regulatory Sequences and Transcription Factors from Oil Palm for Plant Genetic Engineering | UPM |
65. | Genomics and Gene Discovery in Rubber | LGM |
66. | Discovery of New Genes from Plants using Genomics And Bioinformatics | MARDI |
67. | Suppression and Control of the Spread of Ganoderma Infection In Oil Palm | UPM |
68. | Physiological Manipulations to Stabilize and/or Increase Bioactive Compounds in Phyllanthus sp. for Its Antiviral and Other Health Related Properties | MARDI |
69. | Identification of Yield Related QTLs and Genes for Improvement of Malaysian Rice Cultivars | UKM |
70. | Enhancement of Yield Potential of Malaysian Rice Through Incorporation of Photosynthetic Specific Genes from Echinochloa crus-galli | MARDI |
71. | Production of Mass Culture Organism as Live Feed – Development of Photo-bioreactor for High Density Cell Cultivation of Marine Algae for Subsequence Use as Live Feed for Marine Fish Larviculture | UNISEL |
72. | Multivariate Biotechnology Approaches with Artificial Propagations, Stock Enhancement for Sustainable Exploitation & Commercialization of Malaysians Stichopus spp. | USM |
73. | Mass Fry Production Technology of Epinephelus sp (Grouper) | UKM |
74. | Biotechnology and Genetics for the Improvement of The Malaysia Giant Freshwater Prawn (Macrobrachium rosenbergii) | UMS |
75. | Development of corn silage based feed for beef cattle production | UPM |
76. | Development of solid state and submerged fermentation technology for the production of Schizophyllum commune | IIUM |
77. | Metabolomic study for The Development of Functional Foods with Anti-Diabetic Property | UPM |
78. | Development of Bioactive Peptides as Food Ingredients from High-Protein Materials Using Nanocarrier Technology | UPM |
79. | Bovine Sperm Sexing Using Flow Cytometry and Immunological Approaches | UM |
80. | Development of Multiple Separation Techniques for High Fertilizing Capacity Bovine | UKM |
81. | Evaluation of Bali cattle meat quality through biotechnological approach | UPM |