Introducing

National Institute of Biotechnology Malaysia Research Project

Research Project

  • RESEARCH PROGRAMME
  • FLAGSHIP
  • INTERNATIONAL COLLABORATION

The core business of NIBM is R&D for the generation of new knowledge and technology innovation. MGI, IPharm & ABI conducted research projects being funded  by ministries and also some collaboration with local and international universities or research institutions/organisations.

ROLLING PLAN 

No.

PROJECT TITLE

Duration

1.

Malaysia Genetics and Living Culture Collection: Safeguarding Research, Development, Innovation And Commercialization Of Biological Materials (NEW)

1 year (2020)

2. 

Program Pembangunan Mampan Benih Rumpai Laut Bagi Industri Aquakultur

3 years (2018-2020)

3.

COMMERCIALISING AN INTEGRATED AAALAC ACCREDITED SPF SMALL LABORATORY ANIMALS BREEDING AND NON-CLINICAL STUDIES RESEARCH CENTRE

4 years ( 2017-2021)

4.

Establishment of a technology platform for pharmaceuticals, nutraceuticals and cosmeceuticals product development and national natural product repository R&D&C

2 years 2016-2018

DSTIN FLAGSHIP Program/ Pre-Commercialisation Projects (10th MP)

No.

PROJECT TITLE

Duration

1.

New Technologies for sustainable Bio-Economy : Construction of microbial Cell Biocatalyst for Production of Biobased Fine Chemicals.

2 years

2.

Enhancing The therapeutic potential of rAF Newcastle Disease Virus Cancer Vaccine.

2 years

3.

Development of a natural products library from Malaysian biodiversity for systematic discovery of potential active therapeutic agents for obesity 

3 years

4.

Drug-drug and Drug-herb interactions screening platform, a comprehensive high throughput safety testing service for drugs, nutraceuticals and standardized herbal medicine in IPharm 

3 years

5.

Development, Evaluation And Integration of Innovative Tools To Reduce Dengue Morbidity And Mortality In Community 

3 years

6.

Enhancing the Productivity of Farm Buffalo (Bubalus Bubalis) Through Modification of Rearing Practices

3 years

INTERNATIONAL COLLABORATION

No.

PROJECT TITLE

COLLABORATOR

1.

Structural Genomics of the Extremophilic Microbes Leucosporidium antarticum and Bacillus lehensis G1

Monash University (Prof. Jamie Rossjohn)

2.

New Technologies for Sustainable Bio-Economy: Construction of Microbial Cell BioCatalyst for Production of Biobased Fine Chemicals 

Concordia University, Montreal, Canada (Prof. Adrian Tsang)

  • MOSTI SOCIAL INNOVATION (MSI)
  • FUNDAMENTAL RESEARCH GRANT
  • SMARTFUND

MOSTI SOCIAL INNOVATION (MSI)

No.PROJECT TITLEYear
1.Penentuan Profil Metabolite Madu Kelulut 2015
2. Teknologi DNA & GPS Terhadap Koloni Kelulut2016
3.Projek The Innovative “eco- ‘CLEAN’” Support Program2015
4. Projek The Natural Cosmeceutical Formulation Workshop2015
5. Projek The Eco-candle Making2015
6.Cosmeceutical workshop with Cymbopogon nardus: Natural Product Invention2017
7.Smart System Mushroom House for Oyster Mushroom Cultivation2015
8.Pembangunan Sistem Fertigasi Bagi Penanaman Tanaman Herba Kaempferia parviflora Secara Berskala Besar2015
9.Program Teknologi Kultur Tisu Tumbuhan Untuk Usahawan Muda Dalam Meningkatkan Ekonomi di Tuaran, Sabah2016
10.Program Pembangunan Usahawan Desa Dalam Penanaman Cendawan di Kimanis, Papar, Sabah2016
11.Program Penghasilan Makanan Ternakan Ruminan Kos Rendah dan Mampan Menggunakan Teknologi Silaj oleh Komuniti di Kawasan Padang Terap, Kedah2017
12.Program pengeluaran benih kumpulan halia (Zingiber spp.) menggunakan teknik tisu kultur dan sistem fertigasi.2017
13.Ternakan Ikan Patin Dalam Tangki Modular Terkawal2017

FUNDAMENTAL RESEARCH GRANT SCHEME (FRGS)-MOE

No.

PROJECT TITLE

Year

1.

Identifying the Novel Features of Diacylglyceryl Transferase (LGT) Membrane Enzyme in Leptospirosis – causing bacteria

2019-2021

2. 

Elucidation Of Crystal Structure And Function Of Enzymes With Phenol Removing Activity From Geobacillus.

2019-2022

3.

Elucidation of the Mechanism of Action And Signal Transduction Pathway Activated by Two Natural Compounds with Anti- Diabetic Potential 

2017-2020

4.

Isolation and structure elucidation of bioactive compound(s) from khaya senegalensis (DESR.) A. Juss. Leaves with wound healing activity”

2019-2021

5.

Mechanistic studies on the mode of actions of standardised bilimbi fraction and its natural compounds in brown fat differentiation program

2019-2021

6.

Iron Biofortification Of Malaysia Rice Using Targeted Genome Editing Approach

2014-2016

7.

Development Of New Strains Of Tiger Milk Mushroom (Lignosus Sp)

2014-2016

8.

Determination the Effects of Indigenous Silage Bacteria and Its Associated Bacterial Communities using Conventional and Next Generation Sequencing Approaches Towards Improved Silage Quality

2018-2020

SMARTFUND (MESTECC)

No.

PROJECT TITLE

Year

1.

RapidRAW Screening Technology: Fake Honey Detection

2019-2021

  • MOSTI SPECIAL ALLOCATION
  • GRANT AWARD
  • LOCAL RESEARCH COLLABORATION

MOSTI SPECIAL ALLOCATION

No.

PROJECT TITLE

Year

1.

Large scale production of tuber of Tiger’s Milk Mushroom (Lignosus rhinocerus)

2015-2017

2.

Identification Of The Growth And Development Of Termitomyces Heimii

2015-2017

3.

Proteomics Of Termitomyces heimii At Different Developmental Stage

2015-2017

4.

Smart System For Shiitake Mushroom (Lentinula edodes) Cultivation

2015-2017

5.

Development of Nutraceutical and Pharmaceutical Products for Therapeutic Indications or Disease of High Burden to Malaysia 

2015-2018

GRANT AWARD

No.

PROJECT TITLE

Year

1.

Skim Sequencing Of 96 Heterotrigona Itama Genome

(Grant Award by Illumina 2017)

2017-2018

LOCAL RESEARCH COLLABORATION

No.

PROJECT TITLE

LEAD BY

1.

Genome Sequencing of local isolates bacteria Lysinibacillus sp. and Enterobacter sp.

UKM

2.

Analisis Mikrobiom yang Terlibat dalam Patogenesis Ganoderma Boninense Terhadap Pereputan Pangkal Batang Pokok Kelapa Sawit, Elaeis guineensis

UKM

3.

Molecular Characterization of Familial Hypercholesterolemia (FH) in a Malay Population via Exome Sequencing

UMBI

4.

Proteomics Footprinting of Tecotrienols-treated Human Breast Cancer Cells.

UM

5.

Genomic Diversity of Malaysian Aborigine (Orang Asli).

UMBI

6.

Genome and transcriptome analyses of four Burkholderia pseudomallei isolated from Malaysia

UKM

7.

Genome Sequencing and Analysis of Rhodococcus sp.

UNISEL

8.

Comparative Genome Analyses and Phylogenomics Studies of Land and Marine Iguanas from the Galapagos Island

UKM

9.

Functional characterization of hypothetical protein from Burkholderia pseudomallei

UKM

10.

Structural Elucidation of Human APOBEC3B, a Cytosine Deaminase implicated in Cancer

UTM

11.

Elucidation of the Neuro - Regenerative Signaling Pathway in Diopatra Claparedii

UMT

12.

Unraveling the enzymes involved in dimerization of resveratrol.

UiTM

13.

Pemuliharaan Genetik Kelip-kelip Pteroptyx tener (Coleoptera: Lampyridae) di Kuala Selangor

FRIM

14.

Generation and Characterization of The Rafflesia Genome Sequence

UKM

15.

Soil microbiome analysis of oil palm for potential Basal Stem Rot disease control

UPM

16.

Comparative Genomics Of Rafflesia

UKM

17.

Highland Stingless Bee Identification And The Assessment Of Domesticated Stingless Bee At High Altitude

UKM

18.

Functional Studies of Mating Pheromones in Oil Palm Pathogen, Ganoderma boninense to Elucidate Its Pathogenicity 

UKM

19.

Targeted genomic Profile of Malay B-Thalassemia Patients by Using NGS 

USM

20.

Penghasilan Madu Premium Berasaskan Inovasi Mustafa-Hive dan Hilda-Sistem

USM

21.

Determination of Molecular Characteristics and Cytotoxicity of Polyphenol from Aquilaria sp. (Gaharu) as Lipase Inhibitor in Obesity Treatment

UPSI

22.

Visualization model of biocatalysis remediation by polycyclic aromatic hydrocarbons-degrading enzymes through functional and structural characterization

UPSI

23.

Elucidation of structure and function of conserved hypothetical proteins related to thermal stress

response in psychrophilic bacterium and yeast

UMS

24.

Mangosteen research sustainability using multi-omics integration and database development

UKM

25.

Projek FRGS-MRSA: Characterisation of nonporous biochar-derived adsorbents from tropical biomass

UPM

26.

Insights into the evolution of fiddler crab through whole genome comparison between Uca rosea with Uca annulipes

USM

27.

Role of recombinant protease derived from Malaysian belacan on eschar and biofilm removal for

necrotic wound healing

UTM

28.

PCOS analysis

LPPKN

29.

Cell Permeability and Bioavailability Evaluation of Citropten and its Anti-Inflammatory Properties in a Rat  Model Inflammation

IMR

30.

Oral pharmacokinetic evaluation of freeze-dried Carica papaya leaves juice formulations in rats 

IMR

31.

The Possible Use of Mitochondria as Indicator in Production Yield and Abnormality of Oil Palm

MPOB

32.

Traceability and Authenticity of Honey and Kelulut Honey

BKKM (MOH)

33.

Development of entomopathogenic fungi as biocontrol agents against dengue vectors

Swinburne University of Technology Sarawak Campus

34.

Fitness assessment of dengue diagnostic methods for safe utilisation

UM

35.

Safety of blood and tissues supply

UM

36.

Dengue in marginalized populations

UM

37.

Point of care test (POCT) for Dengue

UM

38.

An integrated microfluidics system for rapid serotype-specific detection of dengue virus infection

UM

39.

Development of New Tools for the Diagnosis and Management of Dengue in Local Communities (CLINICAL)

Monash University

40.

Multi-Centre Field Trial diagnostic Kit for the Identification of potential severe dengue (PARA CLINICAL)

UM

41.

Production and trial use of Spokojan (Community Empowerment)

UM

42.

Design and synthesize lead compounds for anti-dengue based on the bioactive natural products and novel L-thionucleoside pyrimidine analogues using Vorbruggen Coupling Method

UKM/USM

43.

Elucidation of Immune modulatory molecules from Carica papaya extract against Dengue fever

USM

44.

Investigation of the effects of natural products in reducing the progression of atherosclerosis

UMT

45.

Progressing towards discovery of anti-infective entities from natural product: Elucidation of pathways involved in anti-infective using the Caenorhabditis elegans model system

USM

46.

Development of a natural products library from Malaysian biodiversity for systematic discovery of potential active therapeutic agents for obesity 

UKM, USM, UM

47.

Molecular Biopharming of Nipah Virus Surface Antigens for The Production of Recombinant Vaccine

MARDI

48.

Development of Vaccines Against H5N1 and Characterization of The Vaccine Induced Immune Responses and Immunity

UPM

49.

Advanced Reproductive Biotechnology of Seladang and Banteng

MARDI

50.

Application of Advanced Reproductive Biotechnologies for Breeding and Mass Propagation of Malayan Porcupine (H. brachyurus)

PERHILITAN

51.

Genetic Characterization and Intensive Breeding of Malaysian Barking Deer (Kijang) in Developing It As An Alternative Food Source, A Model for Ruminant Health Research and Agro-tourism

UPM

52.

Development and Evaluation of Fermented PKE Based Feed for Poultry and Fish

MARDI

53.

Bio-processed OPF as animal feed 

MARDI

54.

Bio-processed Palm Oil Mill Effluent (POME) for Poultry Feed

MARDI

55.

Development of A Recombinant Single Cell Protein Organism Capable of Bio-synthesizing High Unsaturated Fatty Acids as Feed for Aquaculture

USM

56.

Phylogenetics and Molecular Characterization of The Variant Surface Glycoproteins (VSGs), and Antigenic Repertoire of Trypanosoma evansi in Malaysia

UPM

57.

Process Improvement Of Newcastle Disease Virus (NDV) Vaccine Production In Bioreactor

IIUM

58.

Development of Diagnostic Kit for Detection of Nodavirus from Aquaculture Marine Fish

UMS

59.

Molecular Epidemiology and Pathogenesis of Streptococcus Infection in Caged-cultured Freshwater Fishes

FRI

60.

Production Red Fermented Rice as An Alternative for Feed Ingredients for Development Low Cholesterol Eggs and Low Cholesterol Prawns

MARDI

61.

Reproductive, Breeding and Culture Technologies for Commercial Production of Kelah, Tor spp.

UPM

62.

Development of Antioxidant-rich Products from Local Fruits

MARDI

63.

Molecular Markers for Quality Control of Clonal Oil Palm

MPOB

64.

Tissue-specific Regulatory Sequences and Transcription Factors from Oil Palm for Plant Genetic Engineering

UPM

65.

Genomics and Gene Discovery in Rubber

LGM

66.

Discovery of New Genes from Plants using Genomics And Bioinformatics

MARDI

67.

Suppression and Control of the Spread of Ganoderma Infection In Oil Palm

UPM

68.

Physiological Manipulations to Stabilize and/or Increase Bioactive Compounds in Phyllanthus sp. for Its Antiviral and Other Health Related Properties

MARDI

69.

Identification of Yield Related QTLs and Genes for Improvement of Malaysian Rice Cultivars

UKM

70.

Enhancement of Yield Potential of Malaysian Rice Through Incorporation of Photosynthetic Specific Genes from Echinochloa crus-galli

MARDI

71.

Production of Mass Culture Organism as Live Feed - Development of Photo-bioreactor for High Density Cell Cultivation of Marine Algae for Subsequence Use as Live Feed for Marine Fish Larviculture

UNISEL

72.

Multivariate Biotechnology Approaches with Artificial Propagations, Stock Enhancement for Sustainable Exploitation & Commercialization of Malaysians Stichopus spp.

USM

73.

Mass Fry Production Technology of Epinephelus sp (Grouper)

UKM

74.

Biotechnology and Genetics for the Improvement of The Malaysia Giant Freshwater Prawn (Macrobrachium rosenbergii)

UMS

75.

Development of corn silage based feed for beef cattle production

UPM

76.

Development of solid state and submerged fermentation technology for the production of Schizophyllum commune

IIUM

77.

Metabolomic study for The Development of Functional Foods with Anti-Diabetic Property

UPM

78.

Development of Bioactive Peptides as Food Ingredients from High-Protein Materials Using Nanocarrier Technology

UPM

79.

Bovine Sperm Sexing Using Flow Cytometry and Immunological Approaches

UM

80.

Development of Multiple Separation Techniques for High Fertilizing Capacity Bovine

UKM

81.

Evaluation of Bali cattle meat quality through biotechnological approach

UPM